Citrulline Malate is a compound made up of Citrulline, a non-essential amino acid that is primarily found in watermelons. The malate, or malic acid, is an apple derivative and enhances the positive effects of citrulline. Malic acid takes part in aerobic cellular respiration where oxygen and a carbon compound (acetyl Co-A) are used to produce immediate energy and CO2 in the mitochondria of the cell in what is called the Krebs cycle, a major producer of aerobic energy within the mitochondria. Malate is responsible in the process of recycling lactate and pyruvate to promote efficient energy production and protect muscles from fatigue.This combination provides athletes a new and unique opportunity to fight muscle fatigue and improve sports performance while speeding up and enhancing muscle and energy recovery post intense exercise. Citrulline Malate has several positive effects on aerobic exercise performance including: 1) increased aerobic production of energy; 2) Improved stamina and fatigue resistance, and; 3) improved recovery and energy levels.
Citrulline will assist you in training harder and longer during intense exercise sessions in a similar manner to the energy production of creatine, without any side effects of cramping, bloating or water retention. Recent research studies suggest that Citrulline is even more effective than arginine for enhancing overall plasma arginine levels. The reason for this is Citrulline’s effects on endogenous arginine synthesis. This leads researchers to believe that Citrulline may indeed be more potent at nitric oxide (NO) production than supplementing with arginine and AAKG supplements. Citrulline has also been demonstrated to be very effective at growth hormone (GH), insulin, and creatine production. In studies of Citrulline Malate supplementation in the 6 gram dose range, that it is highly effective at increasing ATP production by 30%, significantly reducing muscle fatigue and a dramatic increase in phosphocreatine levels post exercise.
Citrulline functions to remove endotoxins to prevent lactic acid and ammonia build up, by acting as an intermediary in the Urea Cycle. These endotoxins impair overall exercise performance and are produced by the body in response to intense physical exercise, protein metabolism and catabolic states. Citrulline supplementation rapidly speeds up the removal of these lactic acid and ammonia waste products from your working muscles, resulting in a better performance from the working muscle tissue and allowing you to train harder and recover much faster with each and every workout.
Citrulline Malate’s key function is it improves endurance and is widely used by many top athletes for that purpose alone. Citrulline Malate usually yields noticeable performance results in 15 days or less, but will immediately begin to work on clearing toxins from the body, increasing overall energy, and strengthening the immune system. Some users have reported noticeable results in as little as a week, but most will see results in no later than 15 days. In a human clinical study researchers examined the effects of supplementation with six grams of citrulline malate daily for 15 days. Results showed that citrulline malate supplementation led to a significant reduction in the sensation of fatigue following exercise, a 34% increase in the rate of oxidative ATP production during exercise, and a 20% increase in the rate of phosphocreatine recovery after exercise.