Here’s what Biotest’s TC had to say about the new Rez-V:
Sure, it’s what we’re all about. So it shouldn’t come as a surprise that we spend a lot of time thinking about how to increase Testosterone and how to make it, and consequently you, work better.
The trouble is, there’s a yin to Testosterone’s yang and it’s called estrogen.
When we increase Testosterone, gosh darn it, some of it changes to estrogen or, more specifically, estradiol, in a process called aromatization that takes place mostly in fatty tissues and yes, muscle.
Unfortunately, estrogen does things to us that we don’t like. Estrogen can cause an increase in body fat, a reduction of muscle mass, and even a decrease in strength, not to mention making you want to cry at the end of every episode of Grey’s Anatomy.
It can even cause one of the most embarrassing conditions known to man: gynecomastia, or male breasts.
To make things worse, increased levels of estradiol can then enter the bloodstream and travel to the pituitary and signal it to stop producing the hormone that prompts the testicles to produce Testosterone.
That’s right, estrogen is petty. It wants to keep Testosterone levels from going higher.
Furthermore, a lot of us believe that estrogen plays more of a role in promoting prostate cancer than the other Testosterone metabolite that generally gets most of the blame, DHT.
If only our body’s own production of estrogen were the only problem! Unfortunately, modern man is besieged by chemicals in the environment that mimic estrogen. These phony estrogens, known as xenoestrogens, exist in plastic bowls and bottles, air fresheners, pesticides, even toothpaste. They’re literally all over the place and far too many find their way into your body every single day.
These xenoestrogens can have negative effects on the immune system, mucking up memory, behavior, and even the ability to learn, not to mention the effects caused by regular run-of-the-mill estrogen that I mentioned above.
While there are plenty of substances that combat estrogen, it’s a tricky business. The thing is, men need some estrogen to maintain the health of blood vessels. Too little estrogen and the things get all brittle and inelastic. Not good.
So how do you manage estrogen so that you’re able to keep Testosterone levels optimally high, body fat low, and strength high while still maintaining blood vessel health?
Thanks for asking, Papi.
There’s a substance in nature that’s been the subject of a whole lot of worldwide research lately. It’s called resveratrol and it’s a polyphenol found in such foods as peanuts, grapes (and consequently, wine), and mulberries.
Resveratrol has a whole lot of good things going for it, but the one we’re most interested in has to do with estrogen. You see, resveratrol acts as a potent estrogen antagonist (while also acting as an agonist in some tissues, similar to the drugs clomiphene and tamoxifen).
In higher concentrations, it acts as an aromatase inhibitor. That means that it stops the body from whittling away at your Testosterone.
This is cool because if a substance stops Testosterone from being converted to estrogen or estradiol, it not only prevents the nasty effects of estrogen (loss of muscle and strength and accrual of body fat), but it increases your level of Testosterone, leading to additional strength and muscle!
What’s equally important is that it won’t cause your Testicles to go on vacation, i.e. shrink. The testicles don’t get a signal from the pituitary to shut down because estrogen has been curtailed!
There’s a lot of good data in animal models to back this up. Studies have demonstrated a resveratrol-fueled increase in Luteinizing Hormone and Follicle Stimulating Hormone (the pituitary hormones that signal the testicles to start producing Testosterone) that’s 2.7 times greater than placebo.
Additionally, resveratrol caused a 76% increase in sperm count, all of this without any adverse effects. (1)
The aromatase inhibition is thought to occur through two mechanisms: reducing the expression of aromatase, as well as binding to the enzyme and preventing it from doing its dirty work.
And, unlike conventional aromatase inhibitors, resveratrol doesn’t cause a decline in endothelial (blood vessel) function. In fact, it seems to improve it! (2-12)
And remember those nasty xenoestrogens I mentioned earlier? Resveratrol seems to occupy the receptor sites, or biological “parking lots,” so that these xenoestrogens can’t “park” in their spots. That’s good.
MORE GOOD STUFF
While athletes should no doubt be excited about these Testosterone-increasing, estrogen-lowering effects of resveratrol, male and female Life Extension people have been all over this substance for other reasons.
An overwhelming amount of literature on resveratrol has demonstrated potent cardiovascular benefits, anti-aging effects, powerful anti-cancer effects, anti-arthritic, and neurological effects (e.g. potential benefits in treating Alzheimer’s Disease). Many of these benefits seem to stem from anti-oxidative and anti-inflammatory effects as well as gene modulation. (13-21)
What the Life Extension people are most excited about, though, is that resveratrol might actually extend lifespan.
Remember those calorie deprivation people that believed you could extend your lifespan considerably by just munching on a ridiculously low number of calories each day?
Well, one proposed mechanism by which calorie deprivation can make you live longer is that it activates a protein called SIRT1 (sirtuin 1). Activation of this protein inhibits PPAR-gamma activity and this causes your body to burn fat.
It’s not hard to imagine that having less fat might cause you to live longer, but remarkably, resveratrol activates this very same SIRT1 protein.
So even if you’re not concerned with extending your life at this point, resveratrol can cause your body to burn fat.
Maybe you’ve heard of the “French Paradox” (and no, it has nothing to do with why their star soccer player would head butt a guy in the finals of the World Cup)?
It’s the medical puzzle where certain populations (French and Greek) seem to experience a low incidence of coronary heart disease while eating a diet high in saturated fat. Epidemiologists have reasoned that it has to do with their daily consumption of red wine.
Well, many researchers have gone one step further and concluded that it was the resveratrol in the wine that was responsible for the French Paradox. (22-25)
This miracle substance has also been shown to have impressive anti-fungal and anti-viral properties, and may even protect the liver from excessive alcohol consumption or oxidative damage from taking too much acetaminophen. (26-39)
If all that wasn’t enough, there’s a good deal of data demonstrating that resveratrol is an extremely promising compound for the prevention and treatment of prostate cancer! (40-48)
So if taking Testosterone-boosting supplements has made you wary before because of possible prostate risks, resveratrol seems like the answer to your prayers.
QUIT TEASING ME
Quit teasing you? Oh, okay.
If there’s an exciting compound out there, Tim and I want it; we want it for ourselves and we figure that if we want it, chances are you want it too.
That’s why Biotest has been working on the isolation of pure resveratrol for the last year, and why we’re introducing our newest supplement, REZ-V. Each bottle of REZ-V contains 60 capsules of the purest, highest-grade of resveratrol possible.
Our recommended dosage of REZ-V is three capsules once per day. It’s best to take one large dose of resveratrol, instead of several smaller doses, because of the way it’s metabolized. In essence, you want to overwhelm the body’s ability to inactivate and excrete resveratrol, which is done through sulfation and glucuronidation (adding sulfate and beta-glucuronide groups).
This “overwhelming” process is accomplished at about 200 mg taken in one shot. A three-capsule dose contains 600 mg of pure resveratrol, which is also the dose we believe delivers the greatest benefit for the least cost.
Unlike a lot of other supplements, REZ-V doesn’t have to be cycled. In fact, because of the super-powerful health and protective benefits, we recommend all males over 18 take REZ-V every day.
With REZ-V you get the following possible benefits:
• Acts as both an estrogen antagonist and an aromatase inhibitor.
• Increases Testosterone without causing testicular shutdown
• Promotes blood vessel health and cardiovascular health in general
• Exhibits anti-cancer effects, particularly anti prostate-cancer effects
• Exhibits anti-aging effects
• Promotes fat loss
• Has anti-inflammatory properties
• Acts as an anti-oxidant
• Exhibits anti-arthritic effects
• Shows anti-fungal and anti-viral effects
• Acts as a liver protectant
Excuse me for saying so, but that’s all pretty damn cool.
The cost for this wonder supplement? An extraordinarily low $89.95 per bottle. That’s a whole lot of benefit for not a whole lot of money.
Whether you’re interested in increased Testosterone and decreased estrogen, along with reduced levels of body fat, or just want to be healthier and possibly live longer, REZ-V has got to be part of your daily supplement arsenal.
1. Juan ME, et al. “trans-Resveratrol, a natural antioxidant from grapes, Increases sperm output in healthy rats.” J Nutr. 2005 Apr;135(4):757-60.
2. Bhat KP, et al. “Estrogenic and antiestrogenic properties of resveratrol in mammary tumor models.” Cancer Res. 2001 Oct 15;61(20):7456-63.
3. Henry LA, Witt DM. “Resveratrol: phytoestrogen effects on reproductive physiology and behavior in female rats.” Horm Behav. 2002 Mar;41(2):220-8.
4. Matsumura A, Ghosh A, Pope GS, Darbre PD. “Comparative study of oestrogenic properties of eight phytoestrogens in MCF7 human breast cancer cells.” J Steroid Biochem Mol Biol. 2005 Apr;94(5):431-43.
5. Bowers JL, et al. “Resveratrol acts as a mixed agonist/antagonist for estrogen receptors alpha and beta.” Endocrinology. 2000 Oct;141(10):3657-67.
6. Lu R, Serrero G. “Resveratrol, a natural product derived from grape, exhibits antiestrogenic activity and inhibits the growth of human breast cancer cells.” J Cell Physiol. 1999 Jun;179(3):297-304.
7. Turner RT, et al. “Is resveratrol an estrogen agonist in growing rats?” Endocrinology. 1999 Jan;140(1):50-4.
8. Bhat KP, Pezzuto JM. “Resveratrol exhibits cytostatic and antiestrogenic properties with human endometrial adenocarcinoma (Ishikawa) cells.” Cancer Res. 2001 Aug 15;61(16):6137-44.
9. Wang Y, et al. “The Red Wine Polyphenol Resveratrol Displays BI-Level Inhibition on Aromatase in Breast Cancer Cells.” Toxicol Sci. 2006 Apr 11; E-Published Ahead of Print
10. Wallerath T, et al. “A blend of polyphenolic compounds explains the stimulatory effect of red wine on human endothelial NO synthase.” Nitric Oxide. 2005 Mar;12(2):97-104.
11. Lekakis J, et al. “Polyphenolic compounds from red grapes acutely improve endothelial function in patients with coronary heart disease.” Eur J Cardiovasc Prev Rehabil. 2005 Dec;12(6):596-600.
12. Buluc M, Demirel-Yilmaz E. “Resveratrol decreases calcium sensitivity of vascular smooth muscle and enhances cytosolic calcium increase in endothelium.” Vascul Pharmacol. 2006 Apr;44(4):231-7.
13. Labinskyy N, et al. “Vascular dysfunction in aging: potential effects of resveratrol, an anti-inflammatory phytoestrogen.” Curr Med Chem. 2006;13(9):989-96.
14. Bhat KPL, et al. “Biological effects of resveratrol.” Antioxid Redox Signal. 2001 Dec;3(6):1041-64.
15. Bradamante S, et al. “Cardiovascular protective effects of resveratrol.” Cardiovasc Drug Rev. 2004 Fall;22(3):169-88.
16. de la Lastra CA & Villegas I. “Resveratrol as an anti-inflammatory and anti-aging agent: mechanisms and clinical implications.” Mol Nutr Food Res. 2005 May;49(5):405-30.
17. Delmas D, Jannin B, Latruffe N. “Resveratrol: preventing properties against vascular alterations and ageing.” Mol Nutr Food Res. 2005 May;49(5):377-95.
18. Valenzano DR, et al. “Resveratrol prolongs lifespan and retards the onset of age-related markers in a short-lived vertebrate.” Curr Biol. 2006 Feb 7;16(3):296-300.
19. Marambaud P, Zhao H, Davies P. “Resveratrol promotes clearance of Alzheimer’s disease amyloid-beta peptides.” J. Biol. Chem 2005 Nov;280(45): 37377-37382
20. Molnar V, Garai J. “Plant-derived anti-inflammatory compounds affect MIF tautomerase activity.” Int Immunopharmacol. 2005 May;5(5):849-56.
21. Elmali N, et al. “Effect of resveratrol in experimental osteoarthritis in rabbits.” Inflamm Res. 2005 Apr;54(4):158-62.
22. Kopp P. “Resveratrol, a phytoestrogen found in red wine. A possible explanation for the conundrum of the ‘French paradox’?” Eur J Endocrinol. 1998 Jun;138(6):619-20.
23. Constant, J. “Alcohol, ischemic heart disease, and the French paradox.” Coron. Artery Dis. 1997; 8:645 — 649.
24. Das, D K, et al. “Cardioprotection of red wine: role of polyphenolic antioxidants.” Drugs Exp Clin Res. 1999;25(2-3):115-20.
25. Soleas GJ, Diamandis EP, Goldberg DM. “The world of resveratrol.” Adv Exp Med Biol. 2001;492:159-82.
26. Wyke SM, Tisdale MJ. “Induction of protein degradation in skeletal muscle by a phorbol ester involves upregulation of the ubiquitin-proteasome proteolytic pathway.” 2006 May;78(25):2898-2910
27. Tisdale MJ. “The ubiquitin-proteasome pathway as a therapeutic target for muscle wasting.” J Support Oncol. 2005 May-Jun;3(3):209-17.
28. Wyke SM, Russell ST, Tisdale MJ. “Induction of proteasome expression in skeletal muscle is attenuated by inhibitors of NF-kappaB activation.” Br J Cancer. 2004 Nov 1;91(9):1742-50.
29. Borra MT, Smith BC, Denu JM. “Mechanism of human SIRT1 activation by resveratrol.” J Biol Chem. 2005 Apr 29;280(17):17187-95.
30. Picard F, et al. “Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma.” Nature. 2004 Jun 17;429(6993):771-6.
31. Wolf G. “Calorie restriction increases life span: a molecular mechanism.” Nutr Rev. 2006 Feb;64(2 Pt 1):89-92.
32. Ingram DK, et al. “Calorie restriction mimetics: an emerging research field.” Aging Cell. 2006 Apr;5(2):97-108.
33. Roth GS, Lane MA, Ingram DK. “Caloric restriction mimetics: the next phase.” Ann N Y Acad Sci. 2005 Dec;1057:365-71.
34. Tian WX. “Inhibition of fatty acid synthase by polyphenols.” Curr Med Chem. 2006;13(8):967-77.
35. Kasdallah-Grissa A, et al. “Protective effect of resveratrol on ethanol-induced lipid peroxidation in rats.” Alcohol Alcohol. 2006 May-Jun;41(3):236-9
36. Sener G, et al. “Protective effects of resveratrol against acetaminophen-induced toxicity in mice.” Hepatol Res. 2006 Apr 1; E-Published Ahead of Print
37. Docherty JJ, et al. “Effect of resveratrol on herpes simplex virus vaginal infection in the mouse.” Antiviral Res. 2005 Sep;67(3):155-62.
38. Jung HJ, et al. “Fungicidal effect of resveratrol on human infectious fungi.” Arch Pharm Res. 2005 May;28(5):557-60.
39. Palamara AT, et al. “Inhibition of influenza A virus replication by resveratrol.” J Infect Dis. 2005 May 15;191(10):1719-29.
40. Yoo KM, et al. “Potent Inhibitory Effects of Resveratrol Derivatives on Progression of Prostate Cancer Cells.” Arch Pharm (Weinheim). 2006 Apr 18;339(5):238-241
41. Jones SB, et al. “Resveratrol-induced gene expression profiles in human prostate cancer cells.” Cancer Epidemiol Biomarkers Prev. 2005 Mar;14(3):596-604.
42. Scifo C, et al. “Resveratrol and propolis as necrosis or apoptosis inducers in human prostate carcinoma cells.” Oncol Res. 2004;14(9):415-26.
43. Kim YA, et al. “Antiproliferative effect of resveratrol in human prostate carcinoma cells.” J Med Food. 2003 Winter;6(4):273-80.
44. Stewart JR, Artime MC, O’Brian CA. “Resveratrol: a candidate nutritional substance for prostate cancer prevention.” J Nutr. 2003 Jul;133(7 Suppl):2440S-2443S.
45. Ratan HL, et al. “Resveratrol — a prostate cancer chemopreventive agent?” Urol Oncol. 2002 Nov-Dec;7(6):223-7.
46. Aggarwal BB, et al. “Role of resveratrol in prevention and therapy of cancer: preclinical and clinical studies.” Anticancer Res. 2004 Sep-Oct;24(5A):2783-840.
47. Aziz MH, Kumar R, Ahmad N. “Cancer chemoprevention by resveratrol: in vitro and in vivo studies and the underlying mechanisms (review).” Int J Oncol. 2003 Jul;23(1):17-28.
48. Delmas D, et al. “Resveratrol as a chemopreventive agent: a promising molecule for fighting cancer.” Curr Drug Targets. 2006 Apr;7(4):423-42.